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NEW IN GENE REGULATION

Cover of the Thematic Minireview Series 2015: Metals at the Host-Pathogen InterfaceThematic Minireview Series 2015:
Metals at the Host-Pathogen Interface

Coordinating Editor: F. Peter Guengerich
 
 

GENE REGULATION IN PRESS

Zhiqiang Cai, Ran Cao, Kai Zhang, Yuanchao Xue, Chen Zhang, Yu Zhou, Jie Zhou, Hui Sun, Xiang-Dong Fu
First Published on Jun 27, 2015
Ramkumar Mohan, Yiping Mao, Shungang Zhang, Yuwei Zhang, Chengran Xu, Gérard Gradwohl, Xiaoqing Tang
First Published on Jun 24, 2015
Danielle L. Tomasello, Amy M. Gancarz-Kausch, David M. Dietz, Arin Bhattacharjee
First Published on Jun 22, 2015
Sarah K. Sasse, Zheng Zuo, Vineela Kadiyala, Liyang Zhang, Miles A. Pufall, Mukesh K. Jain, Tzu L. Phang, Gary D. Stormo, Anthony N. Gerber
First Published on Jun 18, 2015
Shebli Mehrazarin, Wei Chen, Ju-Eun Oh, Zi X. Liu, Kyung L. Kang, Jin K. Yi, Reuben H. Kim, Ki-Hyuk Shin, No-Hee Park, Mo K. Kang
First Published on Jun 17, 2015

Best of 2014

Yu Wang
December 05, 2014 The Journal of Biological Chemistry, 289, 33808-33813.

PAPERS OF THE WEEK

CLASSICS

Vincent Allfrey. Photo courtesy of the Rockefeller Archive Center.
First Published on Jan 13, 2012
Norton Zinder
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jun 17, 2011
E. Peter Geiduschek
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Dec 24, 2010
Roger D. Kornberg
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Oct 16, 2009
Ira Pastan
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jun 29, 2007
Masayasu Nomura
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Mar 30, 2007
Michael J. Chamberlin. Photo courtesy of /Sigma Xi Today/.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Nov 03, 2006
/a/, Mahlon Hoagland, Paul Zamecnik, and Mary Stephenson. /b/, same 
characters, approximately 35 years later. Reprinted with permission from the 
/Annual Review of Biochemistry/, Vol. 74. © 2005 by Annual Reviews, 
www.annualreviews.org.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 30, 2005
Photo courtesy of the Archives, California Institute of Technology.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 02, 2005
George W. Beadle. Photo courtesy of the National Library of Medicine.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Mar 18, 2005
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REFLECTIONS

*With Linc Sonenshein at a conference at the Pasteur Institute, then a hotbed 
of /B. subtilis/ research.*
Richard Losick
First Published on Dec 22, 2014
*Protein dimer bound to DNA.* The /dashed circles/ represent two identical 
subunits of a protein bound to a 2-fold rotationally symmetric operator. The 
HTH motif on each monomer is indicated, with the recognition helix labeled 
/R/. The /arrows/ show the direction N → C of the recognition helix in each 
monomer. We are dealing here with a simple binding reaction, so the protein 
rapidly comes off and rebinds. The image represents, in effect, a snapshot of 
the protein and DNA at an instant of binding.
Mark Ptashne
First Published on Jan 02, 2014
*The author reading a poem in 1960 at Jacques Monod's 50th birthday.* From 
/left/ to /right/: Sarah Rapkine, Jacques Monod, François Jacob, the author, 
and François Gros. The photo was provided by the Fonds d'Archives Madeleine 
Brunerie at the Institut Pasteur.
Jean-Pierre Changeux
First Published on Jul 22, 2013
*James E. Darnell, Jr.*
James E. Darnell Jr.
First Published on Mar 22, 2013
E. Peter Geiduschek
First Published on May 28, 2010
*Adrift in 1970.*
Christine Guthrie
First Published on Oct 30, 2009
*Intron-containing /td/ gene and activity of its products.* /A/, the /td/ 
gene, intron RNA, and protein products. For /DNA/, the /td/ intron (/red/) 
interrupts the exons encoding TS (/yellow/). For /RNA/, shown is the 
secondary structure, with the intron open reading frame (/ORF/) encoding 
endonuclease I-TevI looped out of element P6. The circular spliced intron and 
ligated TS exons are shown below. For /PROTEIN/, TS, the product of ligated 
exons, and I-TevI, the intron endonuclease, are shown. /B/, group I intron 
splicing pathway. The /td/ intron splices by guanosine attack (/G-OH/) on the 
5′-splice site (/step 1/). Transesterification by the 3′-OH of the 
upstream exon results in ligated exons and a free intron (/step 2/), which 
cyclizes (/step 3/). /C/, homing of the /td/ intron. I-TevI (/dumbbell/), 
encoded by the intron (/step 1/), cleaves the recipient homing site (/step 
2/), and after resection of the cleaved DNA (/step 3/), synapsis occurs 
(/step 4/). DSBR or SDSA, followed by repair, yields homing products (/step 
5/).
Marlene Belfort
First Published on Aug 26, 2009
*Gene order is conserved between two fungi that diverged over 100 million 
years ago.* /Saccharomyces/ is a budding yeast, and /Ashbya/ is a filamentous 
fungus, as shown. The depiction of the chromosomes shows the order of genes 
in each organism. The /Petri plates/ on the left show the mode of growth of 
each on solid medium. The function of each of these genes has no obvious 
relationship to those residing on the same chromosome (see below). There are 
some gene differences interspersed between those genes that are syntenic (see 
Ref. 22 for complete data). Grx1 is a disulfide oxidoreductase. Lsb5 binds a 
protein involved in actin patch assembly and polymerization. YCL033C is a 
methionine-/R/-sulfoxide reductase. Ste50 is an adaptor protein involved in 
mating-type signal transduction. Rrp7 is a protein involved in ribosomal RNA 
processing. His4 is a multifunctional protein encoding the 2nd, 3rd, and 10th 
steps in histidine biosynthesis. Bik1 is a microtubule-associated protein. 
Rnq1 is a prion-like protein.
Gerald R. Fink
First Published on Jun 10, 2009
*Differential gene expression in eggs and stage 10 and 41 embryos of /X. 
laevis./* The figure has been rearranged from Ref. 20. Clones from two 
embryonic cDNA libraries were transferred to nitrocellulose membranes. The 
/numbers/ at the top and bottom refer to columns of clones that are not 
precisely aligned on the different filters; /lines/ indicate the 
corresponding positions on the three filters. The three replicate membranes 
containing transferred colonies were hybridized with labeled cDNA probes 
generated from RNA of the stages (/St/) indicated. Similarities and 
differences in the expression patterns at different stages can be seen. For 
further explanations, see text.
Igor B. Dawid
First Published on Jan 21, 2009
Thioredoxin and glutaredoxin systems. Figure courtesy of the Beckwith Lab, 
Department of Microbiology and Immunology, Harvard Medical School.
Jon Beckwith
First Published on Jan 07, 2009
*The mentors during my postdoctoral time.* /a/, Sol Spiegelman with his wife, 
Helen Spiegelman (1958). /b/, J. D. Watson, S. Benzer, and myself (from left 
to right) at a meeting in 1990.
Masayasu Nomura
First Published on Dec 12, 2008
Sidney Weinhouse, Richard W. Hanson, and Woon Ki Paik at the Fels Research 
Institute, Temple University School of Medicine, Philadelphia, PA in June of 
1978.
Richard W. Hanson
First Published on Nov 20, 2004
John B. Gurdon. Photo taken in 2000.
Donald D. Brown
First Published on Aug 12, 2004
*Early speculation on how a suppressor mutation might restore synthesis of an 
active tryptophan synthetase protein (/TS/) in mutant /td2/ but not mutant 
/td1/.* It was assumed that the /td/gene was altered differently in the two 
mutants. This allowed the product of a specific suppressor gene to act on the 
altered template of mutant /td2/, the CRM+ mutant, to produce an active 
tryptophan synthetase enzyme. Copied with permission from Academic Press 
(12).
Charles Yanofsky
First Published on Jan 29, 2003
Jacques Monod (left) and Georges Cohen (right) measuring β-galactosidase 
activity spectrophotometrically (circa 1954).
Georges N. Cohen
First Published on Oct 25, 2002
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